Mechanism:Paclitaxel's antineoplastic action arises from induction of microtubule formation and stabilisation of microtubules, thereby disrupting normal cell division in the G2 and M phases of the cell cycle.
Uses & Dosage:for the primary ttt of ovarian cancer is 135 mg/m2 infused over 24 hours, followed by cisplatin, and repeated at 3-week intervals. Alternatively 175 mg/m2 may be infused over 3 hours, followed by cisplatin, every 3 weeks. For the secondary ttt of ovarian cancer, the suggested Dose as a single agent is 135 or 175 mg/m2 infused over 3 hours once every 3 weeks. For breast cancer, a Dose ofpaclitaxel 175 mg/m2 infused over 3 hours once every 3 weeks is recommended for adjuvant treatment (for 4 courses). When used first-line with doxorubicin, paclitaxel 220 mg/m2 is infused over 3 hours once every 3 weeks; the Dose is given 24 hours after doxorubicin. In non-small cell lung cancer, the recommended Dose is 135 mg/m2 over 24 hours or 175 mg/m2 over 3 hours, followed by cis latin, and re eated at 3-week intervals.
Vial
1134 EGP
Mechanism:Paclitaxel's antineoplastic action arises from induction of microtubule formation and stabilisation of microtubules, thereby disrupting normal cell division in the G2 and M phases of the cell cycle.
Uses & Dosage:for the primary ttt of ovarian cancer is 135 mg/m2 infused over 24 hours, followed by cisplatin, and repeated at 3-week intervals. Alternatively 175 mg/m2 may be infused over 3 hours, followed by cisplatin, every 3 weeks. For the secondary ttt of ovarian cancer, the suggested Dose as a single agent is 135 or 175 mg/m2 infused over 3 hours once every 3 weeks. For breast cancer, a Dose ofpaclitaxel 175 mg/m2 infused over 3 hours once every 3 weeks is recommended for adjuvant treatment (for 4 courses). When used first-line with doxorubicin, paclitaxel 220 mg/m2 is infused over 3 hours once every 3 weeks; the Dose is given 24 hours after doxorubicin. In non-small cell lung cancer, the recommended Dose is 135 mg/m2 over 24 hours or 175 mg/m2 over 3 hours, followed by cis latin, and re eated at 3-week intervals.
Note: All the provided information about this drug does not substitute for consulting a doctor.