Uses: ovarian cancer, Cervical cancer and lung cancer, as well as other cancer types.
Topoisomerase-l: is a nuclear enzyme that relieves torsional strain in DNA by opening single strand breaks. Once topoisomerase-l creates a single strand break, the DNA can rotate in front of the advancing replication fork. Topotecan intercalates between DNA bases. This intercalation disrupts the DNA duplication machinery when it reaches a site where topotecan is intercalated. This disruption prevents DNA replication, and ultimately leads to cell death. Mammalian cells cannot efficiently repair these double strand breaks. This process leads to breaks in the DNA strand resulting in apoptosis.
Vial
928 EGP
Uses: ovarian cancer, Cervical cancer and lung cancer, as well as other cancer types.
Topoisomerase-l: is a nuclear enzyme that relieves torsional strain in DNA by opening single strand breaks. Once topoisomerase-l creates a single strand break, the DNA can rotate in front of the advancing replication fork. Topotecan intercalates between DNA bases. This intercalation disrupts the DNA duplication machinery when it reaches a site where topotecan is intercalated. This disruption prevents DNA replication, and ultimately leads to cell death. Mammalian cells cannot efficiently repair these double strand breaks. This process leads to breaks in the DNA strand resulting in apoptosis.
Note: All the provided information about this drug does not substitute for consulting a doctor.