Actions Modifies cell cycle by interfering with DNA stucture and function.
Indications:Metastatic testicular and ovarian carcinoma, advanced bladder cancers, refractory squamous cell neck and head Carcinomas
Adverse Effects,and Precautions: a general outline see the beginning of the chapter. Nausea may persist for up to a week. Serious toxic effects on the kidneys, bone marrow, and ears , the effects are Dose —related and cumulative. Damage to the renal tubules during the second week after . Adequate hydration, and use of osmotic diuretics such as mannitol to increase urine volume and thus decrease the urinary concentration of platinum, can reduce the incidence of nephrotoxicity. Electrolyte disturbances, particularly hypomagnesaemia and hypocalcaemia, may occur, possibly as a result of renal tubular damage. I-Ineruricaemia is also seen.
Dosage: Testicular tumors:20 mg / m2 / day I.V. for 5 days (day 1-5) every 3 weeks, for 3 courses. tumor 50 mg / m2 1.V. once every 3 4 weeks.
Vial
57 EGP
Actions Modifies cell cycle by interfering with DNA stucture and function.
Indications:Metastatic testicular and ovarian carcinoma, advanced bladder cancers, refractory squamous cell neck and head Carcinomas
Adverse Effects,and Precautions: a general outline see the beginning of the chapter. Nausea may persist for up to a week. Serious toxic effects on the kidneys, bone marrow, and ears , the effects are Dose —related and cumulative. Damage to the renal tubules during the second week after . Adequate hydration, and use of osmotic diuretics such as mannitol to increase urine volume and thus decrease the urinary concentration of platinum, can reduce the incidence of nephrotoxicity. Electrolyte disturbances, particularly hypomagnesaemia and hypocalcaemia, may occur, possibly as a result of renal tubular damage. I-Ineruricaemia is also seen.
Dosage: Testicular tumors:20 mg / m2 / day I.V. for 5 days (day 1-5) every 3 weeks, for 3 courses. tumor 50 mg / m2 1.V. once every 3 4 weeks.
Note: All the provided information about this drug does not substitute for consulting a doctor.